Drug Addiction
Conditions
Interventions
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Enrollment age: 18-50 years old, no gender limitation; 2. Meet the diagnostic criteria of moderate to severe substance use disorder in DSM-5, and meet the following conditions: (1) Drug addiction course of 3 years or more; (2) Three or more times of drug treatment (medical institutions or compulsory drug treatment) failure; (3) After physiological detoxification treatment (after 14 days), urine tests of morphine, methamphetamine, ketamine, methadone and buprenorphine were negative; 3. The patient and his/her relatives or spouse have fully understood the purpose, significance, efficacy, complications and possible risks of the operation and voluntarily request surgical treatment; 4. The patient and his/her relatives have good compliance, and their relatives can assist researchers to complete follow-up and sign informed consent; 5. Sign the informed consent of the subject.
Exclusion criteria
Exclusion criteria: 1. Patients with other drug dependence (except tobacco dependence); 2. The subjects have no strong willingness to voluntarily detoxify themselves; 3. Have severe cognitive impairment (MMSE score: illiteracy < 17, primary school < 20, junior high school < 24); 4. Patients with other mental diseases (including drug-induced mental disorders); 5, Have a history of active epilepsy (i.e., epileptic seizures), have suffered craniocerebral nervous system injury and other obvious neurological defects; 6. Abnormal blood pressure and blood sugar are difficult to control; preoperative anticoagulant drugs are being taken or clinical bleeding tendency is contraindicated; 7. Preoperative test values of main indexes of liver function were 3 times higher than the upper limit of normal value, and those of main indexes of renal function were 1.5 times higher than the upper limit of normal value; Patients diagnosed with malignant tumors; Serious heart disease; Unstable vital signs with BMI <= 12; 8. Confirmed HIV-positive persons; 9. Surgical history: such as stereotactic neuronucleotomy, implantation of similar products, etc., or other surgical procedures that researchers consider to have an impact on the study within six months; 10. Women who are pregnant or planning to be pregnant or breast-feeding; 11. The patient is participating in other clinical trials and has not obtained the clinical study endpoint; 12. The researcher considers it inappropriate to participate in this clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relapse Rate; | — |
Countries
China
Contacts
Public ContactFan Ni
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed