multi-drug resistance bacterial infection
Conditions
Interventions
Bacteriophage therapy Group:Bacteriophage
Bacteriophage therapy Group:antibiotics
Sponsors
Second Affiliated Hospital of Southern University of Science and Technology(the Third People's Hospital of Shenzhen)
Eligibility
Sex/Gender
All
Age
1 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. 1-90 years old patients with multi-drug resistant bacterial infection (based on the drug susceptibility test results of our hospital or other first-class hospitals in Grade 3); 2. The pathogen infected by the patient should meet one of the following conditions: (1) Pathogens are fully resistant to antibiotics; (2) Pathogens are resistant to key antibiotics; (3) Pathogens are sensitive to critical antibiotics in vitro, but this antibiotic treatment is ineffective or not significantly effective in the body. (4) Pathogenic bacteria that are limited in their use of key sensitive antibiotics (patients with organ function impairment or allergy to this antibiotic) 3. Ability to screen for at least one or more phages matching the resistant organism; 4. the ability to administer the drug by topical application, focal spraying of infection, nebulized inhalation, perfusion, local injection or catheter; 5. the subject and family (or guardian) have fully read, understood and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Bacterial infections can be effectively controlled by antibiotic therapy; 2. here was no effective route of administration other than Intravenous; 3. Over the medical service capacity of the hospital; 4. Patients are unsuitable to participate in this studyarare by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sputum culture;urine culture;fecal culture;Prostatic fluid;Pleural effusion;Puncture fluid;Secretion; | — |
Countries
China
Contacts
Public ContactHongzhou Lu
Outcome results
None listed