Schizophrenia
Conditions
Interventions
High-definition Transcranial Direct Current Stimulation (FZ positive):High-definition Transcranial Direct Current Stimulation (FZ positive)
High-definition Transcranial Direct Current Stimulation(FZ negative):High-definition Transcranial Direct Current Stimulation(FZ negative)
Sponsors
Beijing Huilongguan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. A diagnosis of schizophrenia based on the Diagnostic and Statistical Manual of Mental Disorders,5th Edition (DSM-5) 2. >= 2 past adequate treatment episodes with different antipsychotics and poor response; 3. Equivalent to >= 600 mg of chlorpromazine per day and >= 6 weeks at a therapeutic dosage; 4. PANSS >=70 and CGI-SI >=4; 5. 18–60 years of age; 6. Education years >= 6 years; 7. Right handedness; 8. Voluntarily participate and sign the informed consent (participants and/or legal guardian).
Exclusion criteria
Exclusion criteria: 1. The patient is participating in another interventional study or the patient has participated in another interventional study within the past three months; 2. Contraindications of using HD-tDCS (e.g.: intracranial metal foreign body, cochlear implant, intracranial hypertension); 3. With mental retardation or organic brain disease; 4. Severe weakness, impulsivity, excitement, and uncooperative; 5. Combination of severe depression, anxiety, or substance dependence (excluding nicotine); 6. Organic disabilities in hearing or/visual perception impairment; 7. Unstable or serious physical illness or severe side effect (e.g.: Drug-induced extrapyramidal syndrome, tardive dyskinesia); 8. Pregnancy or breastfeeding; 9. Immunomodulators, neurotropic, and antioxidants use within eight weeks; 10. Infections within two weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of Clinical symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognition;Personal and Social performance;Clinical Global Impression;Metabolites of the tryptophan pathway;imaging data; | — |
Countries
China
Contacts
Public ContactYunlong Tan
Beijing Huilongguan Hospital
Outcome results
None listed