Knee arthroplasty
Conditions
Interventions
control group:no dexamethasone use
Experimental group 1:Intravenous administration of dexamethasone 10mg mixed with normal saline to 10ml + local infiltration of knee joint injection of 100mg ropivacaine mixed with normal saline to 50m
experimental group 2:The patient was given 10ml of normal saline intravenously + 100mg of ropivacaine and 10mg of dexamethasone mixed with normal saline to 50ml for local infiltration of knee joint
experimental group 3:Intravenous administration of dexamethasone 5mg mixed with normal saline to 10ml + local infiltration of knee joint injection of 100mg ropivacaine, 5mg dexamethasone mixed with no
Sponsors
Beijing Jishuitan Hospital
Eligibility
Sex/Gender
Male
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Select patients over 50 years old and under 80 years old who received unilateral knee arthroplasty in our hospital from August 2022 to February 2023; 2. Patients diagnosed with osteoarthritis; 3. ASA I to II; 4. The patient has the ability of independent behavior, understands and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to local anesthetics; 2.Patients with rheumatoid arthritis, ankylosing spondylitis and other inflammatory joint diseases; 3. Patients who have used glucocorticoids in the past 1 year; 4. Patients who used opioids in the past; 5. Patients with liver and kidney insufficiency (ALT or AST> 40U/L, serum creatinine > 133umol/L); 6. Contraindications to local infiltration anesthesia; 7. Patients with chronic pain other than knee joint and ineffective conservative treatment; 8. For patients with severe diabetes, the preoperative glycosylated hemoglobin was more than 7%; 9. Other situations that researchers think are not suitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS(Visual Analog Scale) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Opioid equivalent;Postoperative nausea and vomiting times;Knee range of motion; | — |
Countries
China
Contacts
Public ContactHongyi Shao
Outcome results
None listed