thoracolunbar spinal operation
Conditions
Interventions
Dexmedetomidine group :Intravenous pumping and endotracheal administration of dexmedetomidine
Esticketamine combined with dexmedetomidine group:Intravenous pump and endotracheal administration of dexmedetomidine and intravenous esketamine
Esticketamine group:Intravenous esketamine was administered
Sponsors
The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei)
Eligibility
Sex/Gender
All
Age
60 Years to 89 Years
Inclusion criteria
Inclusion criteria: Elderly patients to be scheduled for thoracolunbar spinal operation under general anesthesia.
Exclusion criteria
Exclusion criteria: Body mass index >= 30 kg/m^2, basic heart rate < 50 times/min, liver and kidney dysfunction, abnormal auditory, intelligence dysplasia, clotting disorders, or anticoagulant drug use history, has a nerve mental illness history, has a history of traumatic brain injuries, has a history of drug or alcohol addiction, always have a cognitive impairment, this study used drugs have a contraindication, ASA grade IV or higher level, difficult airway Or maxillofacial surgery, chronic respiratory disease, a respiratory infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE score;The incidence of postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative VAS score;Cytokine S100-ß levels;Cytokine NSE levels;The incidence of postoperative adverse reactions;Levels of Inflammatory cytokines; | — |
Countries
China
Contacts
Public ContactJunma Yu
Outcome results
None listed