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A multicenter randomized controlled study of preoperative oral administration of branched-chain amino acids in reducing postoperative insulin resistance in colorectal cancer patients

Surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200062590
Enrollment
Unknown
Registered
2022-08-12
Start date
2022-08-10
Completion date
Unknown
Last updated
2023-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

research group:patients intake 600ml drink which contains 18g BCAA 2-4h before operation
control group:patients intake 600ml water 2-4h before operation

Sponsors

Shanghai Tongren Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age 50-80 years old 2. Pathologically confirmed colorectal cancer 3. Planned elective laparoscopic radical resection of colorectal cancer 4. Preoperative ASA (American Society of Anesthesiologists) grade I-III 5.Informed consent was obtained from patients.

Exclusion criteria

Exclusion criteria: 1. Diabetes mellitus diagnosed before or after admission (fasting blood glucose =7.0mmol/L or HbA1c=6.5%) 2. Preoperative insulin resistance (HOMA-IR>2.8) 3. Renal insufficiency requires dialysis, hepatic insufficiency (Child – Pugh grade B and above) 4. Eating disorders caused by gastrointestinal obstruction 5. Pregnant or lactating women 6. Patients with severe mental illness

Design outcomes

Primary

MeasureTime frame
Postoperative blood glucose value (blood glucose value >8.0mmol/L is regarded as abnormally elevated blood glucose);—

Secondary

MeasureTime frame
HOMA-IR;postoperative complications;postoperative hospital stay;—

Countries

China

Contacts

Public ContactSun Peng
sp2082@shtrhospital.com18121225835

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026