Mild Cognitive Impairment
Conditions
Interventions
Precise location group:Individual brain functional connectivity model transcranial magnetic stimulation
Conventional positioning group : Structural MRI based dorsolateral prefrontal transcranial magnetic stimulation
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: The criteria for the identification of mild cognitive impairment in the 2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia Residual Cognitive Impairment: Diagnosis and Treatment of Mild Cognitive Impairment are met, including the following 1. Patient or informant report, or experienced clinician finding of cognitive impairment; 2. Objective evidence (from cognitive testing) of impairment in one or more domains of cognitive functioning; 3. There can be minor impairment of complex instrumental daily abilities while maintaining independence in activities of daily living; 4. A diagnosis of dementia has not been reached; 5. Aged 55-80 years, voluntary participation in this study and informed consent; 6. CDR=0.5 score.
Exclusion criteria
Exclusion criteria: 1. Vascular MCI (those with a history of stroke and a Hachinski Ischemic Index Scale HIS score >5); 2. MCI due to major depression (Hamilton Depression Inventory score > 24); 3. Having other neurological disorders that can cause cognitive dysfunction (e.g., brain tumors, Parkinson's disease, encephalitis, epilepsy, etc.); 4. MCI due to traumatic brain injury; 5. Other systemic diseases that can cause cognitive impairment, such as abnormal thyroid function, severe anemia, syphilis, HIV, etc; 6. Those with seizures as well as a history of psychiatric disorders or congenital mental retardation; 7. Those who have severe hearing and visual impairment and cannot cooperate with the examination; 8. Contraindications to MRI scanning such as pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments in the body; foreign bodies in the eyes, skin or body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare the improvement of cognitive scales of MCI patients in the precision targeting group and the conventional treatment group, and whether there is a significant difference; | — |
Secondary
| Measure | Time frame |
|---|---|
| To analyze the effect of individualized and precise iTBS treatment on neural circuit abnormalities in MCI patients;The relationship between the changes of brain functional connectivity pattern and the therapeutic effect of individualized and precise iTBS was analyzed; | — |
Countries
China
Contacts
Public ContactHua Lin
Xuanwu Hospital Capital Medical University
Outcome results
None listed