epilepsy
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
14 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with intractable temporal lobe epilepsy according to the International League Against Epilepsy criteria, suitable for anterior temporal lobectomy after multidisciplinary preoperative evaluations; 2. Patients with normal brain MRI or with evidence of unilateral hippocampal sclerosis concordant with EEG findings; 3. Patients with no evidence of bilateral hippocampal sclerosis or of a secondary extrahippocampal lesion that may contribute to seizures; 4. Patients are able to complete clinical and imaging follow-up before and after surgery as required; 5. Informed consent has been signed by patients or their legal representative.
Exclusion criteria
Exclusion criteria: 1. Patients with any other neurological disorder, psychiatric disorder or serious systematic disease; 2. Patients with alcohol or other substance abuse; 3. Patients with other structural lesions except hippocampal sclerosis confirmed by postoperative histopathological examination; 4. Patients can not complete MRI scan; 5. Patients are not able to complete clinical and imaging follow-up as required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative seizure outcome;gray matter wolume;cortical thickness;fractional anisotropy;functional connectivity;graph theory parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| amplitude of low frequency fluctuation; | — |
Countries
China
Contacts
Public ContactWei Li
Outcome results
None listed