Spinal cord stimulation combined with repetitive transcranial magnetic stimulation for disorders of consciousness

Research on the assessment and intervention based on neural network surgery for disorders of consciousness

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200062556

Enrollment

Unknown

Registered

2022-08-11

Start date

2022-07-01

Completion date

Unknown

Last updated

2024-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

disorder of consciousness

Interventions

Transcranial magnetic stimulation treatment group:repetitive transcranial magnetic stimulation

Spinal cord stimulation treatment group:Implantable spinal cord stimulation or short term spinal cord stimulation. EEG testing is used to select treatment frequency

Combined treatment group:Spinal cord stimulation combined with repetitive transcranial magnetic stimulation

Eligibility

Sex/Gender

All

Age

14 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Meet diagnostic criteria for disorders of consciousness; 2. Aged 14-75 years, regardless of gender; 3. Having been ill for more than 1 month and having failed to wake up with conventional treatment methods; 4. Basic normal heart, lung, liver, and kidney functions; 5. expected survival time: > 3 months; 6. able to cooperate in the observation of adverse events and efficacy; 7. no serious contraindications to surgery; 8. Written informed consent signed by the patient or his/her legal representative; 9. Negative pregnancy test in female patients.

Exclusion criteria

Exclusion criteria: 1. Neurodegenerative diseases, intracranial infections, and postoperative coma with brain tumors; 2. Those with persistent improvement or deterioration of consciousness within 1 month prior to enrollment; 3. Those with severe complications; 4. Patients who have participated in other clinical trials within three months prior to the trial; 5. Patients with a history of severe allergy or hypersensitivity; 6. Pregnancy, lactation; 7. With other serious medical disorders or serious uncontrollable infections.

Design outcomes

Primary

Measure	Time frame
Coma Recovery Scale-Revised;	—

Secondary

Measure	Time frame
Nociception Coma Scale;Modified Ashworth Scale;electroencephalogram, EEG;mismatch negativity, MMN;Functional Nuclear Magnetic Resonance;Functional near-infrared spectroscopy;	—

Countries

China

Contacts

Public ContactHe Jianghong

Beijing Tiantan Hospital, Capital Medical University

he_jianghong@sina.cn+86 137 1795 1390

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026