Prostate Cancer
Conditions
Interventions
Sponsors
The Seventh Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old, the upper limit is 75 years old. 2. ECOG score 0-3; 3. Patients with pathologically or cytologically confirmed, unresectable, advanced metastatic or relapsed or refractory CRPC who are ineffective to first-line standard therapy. 4. Positive for PSMA, NKG2DLs and FAP (immunohistochemistry or flow cytometry); 5. Heart, liver and kidney function: creatinine = 50%; 6. Have sufficient understanding and voluntarily sign the informed consent; 7. Patients of childbearing potential must be willing to use contraceptive methods.
Exclusion criteria
Exclusion criteria: 1. Have a history of other tumors; 2. Received cytotoxic drugs and glucocorticoids within 2 weeks before cell collection; 3. Active autoimmune disease; 4. Uncontrolled active infection; 5. HIV infection, uncontrolled HBV, HCV, syphilis infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| objective response rate(ORR);Duration of Response(DOR);Progress Free Survival(PFS);Disease Control Rate(DCR);overall survival(OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of side effects; | — |
Countries
China
Contacts
Public ContactPang Jun
The Seventh Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed