Bladder Cancer
Conditions
Interventions
Sponsors
The Seventh Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old, the upper limit is 75 years old. 2. ECOG score 0-3; 3. Patients with pathologically or cytologically confirmed, unresectable, advanced metastatic or relapsed or refractory solid malignant tumors, who are ineffective to first-line standard treatment, and have at least one measurable lesion. 4. Nectin4, NKG2DLs, and FAP positive (immunohistochemistry or flow cytometry); 5. Heart, liver, and kidney function: creatinine = 50%; 6. Have a sufficient understanding and voluntarily sign the informed consent; 7. Patients of childbearing potential must be willing to use contraceptive methods.
Exclusion criteria
Exclusion criteria: 1. Have a history of other tumors; 2. Received cytotoxic drugs and glucocorticoids within 2 weeks before cell collection; 3. Active autoimmune disease; 4. Uncontrolled active infection; 5. HIV infection, uncontrolled HBV, HCV, syphilis infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate(ORR);Duration of Overall Response(DOR);progression-free survival(PFS);disease control rate(DCR);Overall Survival(OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of side effects; | — |
Countries
China
Contacts
Public ContactPang Jun
The Seventh Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed