Depressive disorder
Conditions
Interventions
2:Dexmeditomidine
3:esketamine0.2mg/kg +dexmeditomidine
4:esketamine0.5mg/kg + Dexmeditomidine
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Both male and female, aged from 18 to 65 years, with insomnia and depressive symptoms for 6 months or more; 2. ASA is graded from I to II; 3. Scores of the Pittsburgh Sleep Quality Index and Hamilton Depression Scale are >7; 4. Insomnia Severity Index (ISI)>15; 5. Patients still have insomnia and depressive symptoms after 2 or more different types of drug therapies in the past; 6. Patients participate in the treatments voluntarily and agree to sign the informed consents of anesthesia sleep treatment.
Exclusion criteria
Exclusion criteria: 1. Patients with serious physical illness and mental illness; 2. Patients with severe head trauma, epilepsy, and abnormal EEG manifestations; 3. Patients with previous drug allergies such as ketamine, dexmedetomidine, and propofol; 4. Patients who cannot understand the contents of relevant scales; 5. Patients who are during pregnancy, lactation, or have a short-term pregnancy plan; 6. Patients with hypovolemia and severe heart block; 7. Subjects with any factors that the investigators consider inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5-hydroxytryptamine;brain derived neurotrophic factor; | — |
Countries
China
Contacts
Public ContactWenyuan Wang
Outcome results
None listed