Cardiovascular operation
Conditions
Interventions
L:Low dose alfentainil
H:High dose alfentainil
C:sufenainil
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective cardiac surgery; 2. Age 18~65 years old, gender is not limited; 3. Body mass index (BMI): 18~30 kg/m2; 4. American Society of Anesthesiologists classification (ASA): I~III; 5. The subjects voluntarily participated in the trial and signed the informed consent form of the trial.
Exclusion criteria
Exclusion criteria: 1. The subject expressly refuses to participate in this research; 2. Those who are allergic to opioids, propofol or naloxone drug excipients; 3. Use of beta-blockers, anxiolytics, and antidepressants; 4. Suspected abuse of narcotic analgesics or sedatives, and alcoholics; 5. ECG prompt: heart rate 100 beats/min or severe arrhythmia; 6. A history of acute respiratory tract infection with no cure within 2 weeks; 7. Those with a history of severe heart, brain, lung, liver, kidney or metabolic diseases, those with neuromuscular system diseases (such as myasthenia gravis), and mental diseases; 8. Systolic blood pressure >180 mmHg and (or) diastolic blood pressure >110 mmHg in patients with preoperative hypertension, or <90/60 mmHg in patients with hypotension; 9. Those who have a history of abnormal surgical anesthesia recovery in the past; 10. Those who are predicted to have or have had difficult airway, such as modified Markov classification III-IV; 11. Pregnant or lactating women and patients (including men) who have childbearing plans within 3 months; 12. Other subjects who are considered inappropriate by other researchers to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cTnI and CK-MB;CK-MB; | — |
Countries
China
Contacts
Public ContactLi MengYuan
The First Affiliated Hospital of Nanchang University
Outcome results
None listed