Acute postoperative pain
Conditions
Interventions
Group C:Oxycodone 0.25mg/ml + normal saline to 200ml
background dose 0ml/h, bolus 4ml, interval 5min
Group P:Oxycodone 0.25mg/ml + saline to 200ml, background dose 1ml/h, Bolus 4ml, 5min interval
Group A:Oxycodone 0.25mg/ml + normal saline to 200ml, the first stage (0-6h after surgery): background dose 0ml/h, Bolus 4ml, interval 5min
the second stage (6-24h after surgery): background dose 1ml/h , Bolus 4ml, interval 5min
the third stage (24-72h after surgery): background dose 0ml/h, Bolus 4ml, interval 5min
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. 18 years old <= age <= 75 years old; 2. ASA I or II; 3. 18 kg/m2<BMI<30 kg/m2; 4. elective knee replacement surgery; 5. Received femoral nerve block therapy and postoperative patient-controlled intravenous analgesia (PCIA).
Exclusion criteria
Exclusion criteria: 1. Coagulation dysfunction; 2. Neuropsychiatric diseases requiring drug treatment; 3. Hypersensitivity to local anesthetics, flurbiprofen axetil, and contraindications for use; 4. Severe cardiopulmonary disease; 5. History of preoperative opioid use; 6. Poorly controlled diabetes; 7. Pregnancy or lactation; 8. History of previous knee surgery; 9. Communication barriers, inability to understand pain scores or patient-controlled intravenous analgesia; 10. Failure of nerve block or complications of nerve block are judged by the investigator to be incapable of enrolling in the group; 11. Abnormal liver and kidney function (aspartate aminotransferase (AST) or/and alanine aminotransferase (ALT) and/or total bilirubin (TBiL) >= 2*ULN; serum creatinine (Cr) >= 2*ULN, or dialysis subjects ;); 12. History of drug abuse and/or alcohol abuse in the past 3 months, and alcohol abuse means drinking more than 2 units of alcohol per day on average (1 unit = 360 ml of beer with 5% alcohol content or 45 ml of liquor with 40% alcohol content or 150ml wine; 13. Those who entered the ICU after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in pain scores before and after nerve block disappearance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of fulminant pain within 24 hours after operation;Onset and duration of rebound pain;Oxycodone consumption;Numerical rating scale, NRS;Zhènjìng píngfen 4 / 5,000 Translation results Sedation score;St. Mary's Hospital Sleep Score;EuroQol-5D (EQ-5D);Neuropathic pain;Satisfaction of patients and their families with postoperative analgesia treatment; | — |
Countries
China
Contacts
Public ContactYingying Zhao
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed