Cerebral small vessel disease
Conditions
Interventions
Sponsors
The First Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. 60 patients with cognitive dysfunction related to cerebrovascular disease (with or without Alzheimer's disease) : (1) Outpatients or inpatients in the neurology department of the Center aged 50-80 years; (2) He/she complained of cognitive impairment and was found to have mild cognitive impairment by objective examination, not dementia. CDR score =0.5 or 1; MMSE score >=20 (primary school culture) or >=24 (secondary school culture and above), daily living ability is independent (mRS <=2); (3) Moderate to severe white matter lesions on imaging (Fazekas grade 2,3) were the main inclusion criteria. Other small vascular signs, such as lacunar infarcts (lacunar infarcts), brain microhemorrhage, enlarged perivascular space (EPVS to infarcts), and brain atrophy to infarcts; (4) Imaging evidence of small vascular diseases, mainly white matter lesions, can explain most of the existing cognitive dysfunction. 2. 30 patients with simple AD-derived MCI: (1) Outpatients and inpatients aged 50-80 in the Department of Neurology of the Center; (2) In accordance with the 2011 NIA-AA diagnostic criteria for MCI stage of Alzheimer's disease; 3. 30 normal people: (1) Family members or other staff of outpatients and inpatients in the neurology department of the Center aged 50-80; (2) Normal cognition.
Exclusion criteria
Exclusion criteria: 1. Severe aphasia or other factors that might preclude completion of neuropsychological assessments or MRI; 2. Refusal or inability to give written informed consent to participate in the study or refusal to come for follow up visits; 3. Contraindications for MRI (e.g., pregnancy, metal implants, and claustrophobia); 4. Cortical or large subcortical infarct (=20 mm in diameter), acute hemorrhagic stroke, cardioembolic stroke; 5. Disorders other than Leukoaraiosis and AD that would affect cognition (e.g., Lewy bodies dementia, frontotemporal dementia, autoimmune encephalitis, and etc); 6. Presence of non-vascular leukoencephalopathy, e.g. multiple sclerosis, poisoning, brain radiotherapy, adult white matter dysplasia, metabolic encephalopathy Diseases, etc; 7. Other severe cerebral diseases: e.g., brain malignancy, brain trauma, alcoholic encephalopathy, Creutzfeldt-jakob disease, severe mental disorders, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood biomarkers;EEG;Demographic data;Imaging data; | — |
Countries
China
Contacts
Public ContactBenyan Luo
The First Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed