Postoperative delirium
Conditions
Interventions
Gold Standard:Evaluation of postoperative delirium by confusion assessment method(CAM)
task, 
event-related 
potential, 
biomarkers 
in 
peripheral 
blood 
and 
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Preoperative diagnosis of hip fracture or hip/knee arthritis; 2. Hip fixation or hip/knee replacement under spinal anesthesia; 3. Age >=65 years; 4. American Society of Anesthesiologists Classification I to III.
Exclusion criteria
Exclusion criteria: 1. Schizophrenia, epilepsy, and myasthenia gravis; 2. Inability to read and write or severe visual impairment; 3. Coma, alcohol dependence, and drug addiction; 4. Blind, one eye or both eyes with obvious atrophy, self-reported or evaluated by the investigator with severe cataract, glaucoma, pinkeye, severe inflammation of eye-related tissues, and retinal detachment; 5. Unable to communicate normally as judged by the researcher; 6. Refusal to sign an informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium was assessed by CAM (Confusion Assessment Method);Eye movement task;Event related potential; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative delirium severity was assessed by MDAS (Memorial Delirium Assessment Scale);Indicators of cerebrospinal fluid (Tau, Aß, NFL);Indicators of peripheral blood (Tau, Aß, NFL);3-minute Diagnostic Interview for CAM, 3D-CAM;Confusion Assessment Method of Intensive Care Unit, CAM-ICU;The 4 'A's test;Mini-mental State Examination, MMSE;Montreal Cognitive Assessment, MoCA;Activities of daily living, ADL;The FRAIL Scale;Clinical Dementia Rating, CDR; | — |
Countries
China
Contacts
Public ContactYongzheng Han
Peking University Third Hospital
Outcome results
None listed