Stroke
Conditions
Interventions
Treatment group:Botulinum toxin A injection treatment,regular rehabilitation
Controlt group:Regular rehabilitation
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with ischemic or hemorrhagic stroke between the ages of 16 and 80 years; 2. Patients with the tone of the lower limb muscle of the spastic side greater than grade 1+ as assessed by the modified Ashworth scale; 3. No previous history of lower limb botulinum toxin injections; 4. Patients with poor results or more severe adverse reactions to oral anticonvulsant drugs; 5. Patients and their family members sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who refused to be randomized; 2. Patients with the presence of contracture of the ankle joint; 3. Patients with known contraindications to botulinum toxin type A treatment, such as allergies and the presence of large skin lesions of the area to be injected; 4. Patients with impaired consciousness who are unable to cooperate with botulinum toxin injection treatment; 5. Pregnant and lactating women; 6. Combination of other diseases causing dystonia, such as multiple sclerosis, cerebral palsy, etc; 7. Patients with other serious systemic diseases or clinical critical conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The modified Ashworth scale (MAS) score;Fugl-Meyer Assessment Scale (FMA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Berg Balance Scale (BBS) score;Modified Barthel index (MBI) score;Shear wave elastography values;Muscle thickness;10 Meter Walk test (10MWT); | — |
Countries
China
Contacts
Public ContactYe Xinhua
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed