Chronic hepatitis B
Conditions
Interventions
Group 1:ETV/TDF continuation treatment group
Group 2:ETV/TDF transferred toTAF group
Sponsors
Beijing Youan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Chronic hepatitis B patients, men and women; 2. Age: 18-65 years old; 3. The diagnosis of chronic hepatitis B conforms to the prevention and treatment guidelines of chronic hepatitis B (2019 edition), and the diagnosis of diabetes conforms to the Prevention and treatment guidelines of Type 2 diabetes (2017 edition); 4. After oral drug or insulin treatment, blood glucose control was stable, HbA1c(%)<=7%; 5. The previous single application of ETV/TDF antiviral therapy lasted more than 12 months, but the total duration of previous antiviral therapy was less than 10 years.
Exclusion criteria
Exclusion criteria: 1. Complicated with hepatitis A, E, C, and other hepatitis virus infection; 2. Acute or chronic renal failure; 3. With other serious active physical and mental diseases, including uncontrolled primary kidney, heart, lung, vascular, neurological, immune deficiency disease or malignant tumor; 4. Acute complications of diabetes, such as diabetic ketosis, hyperosmolar coma, acidosis; 5. Those who cannot cooperate with monitoring and follow-up and refuse to sign the informed consent; 6. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood lipids; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine;Quantification of hepatitis B virus ; | — |
Countries
China
Contacts
Public ContactBin Xu
Beijing Youan Hospital, Capital Medical University
Outcome results
None listed