Prostate cancer
Conditions
Interventions
Gold Standard:Pathology of prostate biopsy or radical prostatectomy
combined 
with 
MRI 
and 
18F-PSMA 
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years and <=85 years; 2. ECOG score 0-1; 3. PCa is clinically suspected and have prostate biopsy indications; 4. PSA<=20 ng/mL; 5. No contraindications of MRI and PSMA PET/CT; 6. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. History of urinary tract infection or acute prostatitis within 3 months; 2. Previous prostate biopsy or other prostate surgery, such as transurethral resection of the prostate; 3. Previous endocrine therapy; 4. Previous pelvic radiotherapy; 5. Mental illness is unable to understand surgical procedures and sign informed consent; 6. Contraindications of anesthesia or surgery; 7. Other researchers think it is not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the sensitivity of 18F-PSMA PET/CT combined with MRI and MRI alone in the diagnosis of csPCa; | — |
Secondary
| Measure | Time frame |
|---|---|
| The detection rate of csPCa in three diagnostic modes (MRI alone, PET/CT alone, PET/CT+MRI);Diagnostic efficacy of csPCa in three diagnostic modes (MRI alone, PET/CT alone, PET/CT+MRI);Optimal cut-off value of SUVmax for diagnosis of csPCa by 18F-PSMA PET/CT;Correlation between PI-RADS, SUVmax and pathological stage;Consistency between PI-RADS and PSMA PET/CT diagnoses; | — |
Countries
China
Contacts
Public ContactMing Liu
Beijing Hospital
Outcome results
None listed