Oral squamous cell carcinoma
Conditions
Interventions
Experiment Group:TPF induction chemotherapy
Sponsors
Southern Medical University Shenzhen Stomatology Hospital (Pingshan)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years with primary oral cancer (tongue, buccal mucosa, upper and lower gums, floor of mouth, and hard palate), regardless of gender; 2. Patients with pathologically confirmed oral squamous cell carcinoma: (1) No distant metastasis was clinically diagnosed by chest film, abdominal B-ultrasound, CT, or MR (PET-CT if necessary); (2) Newly diagnosed, stage II-IVa oral squamous cell carcinoma (according to the tight edition standard of AJCC staging manual for OSCC); (3) Induction chemotherapy and surgical treatment are feasible after evaluation and confirmation by specialized surgeon, anesthesiologist, and oncologist; (4) Willing to accept preoperative induction chemotherapy and surgical treatment; 3. KPS score >= 60, Zps score = 1.5*10^9/L, Platelet (PLT) >= 100*10^9/L, Hemoglobin >= 9 g/dl; (2) Liver function: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) = 2.8 g/dl; (4) Renal function: creatinine clearance (CCR) > 60 ml/min; (5) Coagulation function: international normalized ratio (INR) <= 1.5; Partial thromboplastin time (APTT) <= 1.5*ULN; 5. Willing to join the study, sign informed consent, able to abide relevant procedures specified in the protocol.
Exclusion criteria
Exclusion criteria: 1. Have previously received anti-tumor treatment or have other tumor diseases at the same time; 2. Have any active autoimmune disease or has a history of autoimmune disease, hormone or steroid medication; Long term (> 1 year) history of taking psychotropic drugs; Long term (> 3 months) irregular antibiotic use history; Long term (> 1 month) use history of antibacterial mouthwash; Taking probiotics and prebiotics in recent 3 months; Gastrointestinal diseases in recent 3 months; History of acute infection in recent 2 weeks; 3. Patients who cannot guarantee to complete the necessary treatment plan and follow-up; 4. Other situations in which researchers think it is not suitable to be included in the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Species of bacteria;Clinical tumor response; | — |
Countries
China
Contacts
Public ContactWei Wu
Tianjin Medical University General Hospital
Outcome results
None listed