Ovarian cancer
Conditions
Interventions
RRSO group:Risk-reducing salpingo-oophorectomy
RRESDO group:Risk-reducing salpingectomy and delayed oophorectomy
Non-surgical intervention group:No
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. People with high risk of genetic brCA1/2, BRIP1, RAD51C and RAD51D gene mutations or hereditary family history of ovarian cancer or hereditary family history of breast, ovarian and pancreatic cancer; 2. Having or not having children; 3. Age >=40 years (according to NCCN guidelines, patients with BRCA1 gene mutation can undergo prophylactic surgery until they are 35~40 years old after childbirth or insist on it); 4. The population with a family history of hereditary breast cancer, ovarian cancer and pancreatic cancer should be at least 35 years old, combined with the age of diagnosis of the first episode in the family; 5. Patients with breast cancer who are recommended by breast surgeons or oncologists for surgical castration after surgery; 6. Sign informed consent and complete the questionnaire.
Exclusion criteria
Exclusion criteria: 1. Auxiliary examination such as B-ultrasound or other imaging suggested the possibility of malignant tumor; 2. combined with other active malignant tumors except breast cancer; 3. Patients who are unwilling to sign or withdraw informed consent; 4. It is not suitable for inclusion in this study as determined by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CA125;HE4;Imaging manifestation;Ovarian function test; | — |
Countries
China
Contacts
Public ContactZhou Ying
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed