Anesthesia
Conditions
Interventions
P group:Single administration of propofol
P + S group:Administration of propofol and sufentanil in combination
P + K group:Administration of propofol and esketamine in combination
P + L group:Administration of propofol and lidocaine in combination
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Undergo diagnostic upper GI endoscopy under deep propofol sedation; 2. Meet the classification I–III of the American Society of Anesthesiologists (ASA); 3. >18 years old; 4. Give written informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergic reaction to planned medication; 2. Gravis myasthenia; 3. History of psychological problems or psychiatric disease; 4. Morbid obesity/obstructive sleep apnea; 5. Acute upper respiratory infections; 6. Asthma at acute stage; 7. History of unregulated or malignant hypertension, significant ischemic heart disease, severe arrhythmia; 8. Uncontrolled hyperthyroidism; 9. Severe cardiac, liver, and kidney dysfunction and coagulation disorders; 10. Acute upper GI haemorrhage with shock; 11. Severe anaemia; 12. GI obstruction with gastric retention; 13. Seizure disorders, long-term history of sedative and analgesic drug use, and history of allergy; 14. Increased intracranial pressure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of tussis, nausea and vomiting, and/or body movements;Pharmacoeconomic outcomes;Mini-mental State Examination, MMSE;Metabolic equivalent, MET;Sleep changes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of the addition of the first drug;Time of recovery from anaesthesia;Perioperative propofol doses;Incidence of perioperative adverse events;Incidence of postoperative adverse events; | — |
Countries
China
Contacts
Public ContactHou Haijun
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed