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Postoperative individualized PCIA analgesia based on ADRA2A, OPRM and COMT gene single nucleotide polymorphism

Postoperative individualized PCIA analgesia based on ADRA2A, OPRM and COMT gene single nucleotide polymorphism

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200062425
Enrollment
Unknown
Registered
2022-08-05
Start date
2022-08-20
Completion date
Unknown
Last updated
2023-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative analgesia

Interventions

None listed

Sponsors

Chongqing Health Center for Women and Children
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 59 Years

Inclusion criteria

Inclusion criteria: 1. Female, age >= 18 years and < 60 years, ASA I-III; 2. Plan to perform gynecological laparoscopic surgery under general anesthesia and require postoperative PCIA analgesia; 3. Having normal communication ability, could use the postoperative patient-controlled intravenous analgesia pump correctly, and could cooperate to evaluate the pain intensity; 4. No history of narcotic drug allergy; 5. Be able to understand the informed consent contents and make judgments independently, agree to participate in this study and able to sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Mental illness and cognitive defects; 2. Allergic to known analgesic and sedative drugs; 3. With a history of chronic pain or have a long history of using analgesic and sedative drugs; 4. Patients with peripheral neuropathy symptoms or liver and kidney function abnormality; 5. Failure to implement as designed protocol, incomplete data records, or affecting the judgment of pain intensity; 6. Patient refused.

Design outcomes

Primary

MeasureTime frame
Visual analog scale, VAS;

Secondary

MeasureTime frame
Total amount of analgesic drugs;Patient self-rated satisfaction;Pain Catastrophizing Scale, PCS;Pain Sensitivity Questionnaire, PSQ;

Countries

China

Contacts

Public ContactYu Jin

Chongqing Health Center for Women and Children

dodoes@qq.com+86 18623117820

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026