hypopharyngeal squamous cell carcinoma
Conditions
Interventions
one:Induction chemotherapy + surgery + radiotherapy
two:Surgery + radiotherapy or concurrent chemoradiation
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Obtain signed written informed consent or telephone authorization; - Age at the time of surgery>= 18 years and = (see Appendix 1 for details on KPS scoring criteria); - Good follow-up compliance.
Exclusion criteria
Exclusion criteria: - Failure to obtain signed written informed consent and failure to obtain consent such as the patient's telephone; - at the time of admission the patient's TNM is diagnosed in stages of T1, N0 and specific T2, N0 and T4b, N0-3; - Clear distant metastases M1 of hypopharyngeal carcinoma or other malignant neoplasms complicated by hypopharyngeal carcinoma during the period of occurrence; - Patients who have previously been diagnosed with squamous cell carcinoma of the lower pharynx and have been treated with traditional Chinese medicine; - Previous treatment of patients who have not been carried out in accordance with the standard protocol for diagnosis and treatment; - Patients who have developed any malignant tumors in the past 5 years (cured cutaneous basal cell carcinoma or cervical in situ except for cancer); - Anaphylaxis of grade 3-4 known to any drug in the treatment that leads to suspension or reduction of the dose of the drug; - Peripheral neuropathy > grade 1; - any unstable systemic diseases (including active infections, uncontrolled hypertension, unstable angina, angina that has begun to attack in the last 3 months, congestive heart failure, myocardial infarction that occurred within 12 months before admission, severe arrhythmias requiring medical therapy, liver, kidney or metabolic diseases); - Known human immunodeficiency virus (HIV) infection; - Pregnant or lactating women; - Drug/alcohol abuse, or suffering from a mental or psychiatric disorder that may interfere with the study of compliance; - patients with epilepsy who require medication (for example, steroids or antiepileptic drugs); - Situations where the researcher deems it inappropriate to join the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall svrvival; | — |
Secondary
| Measure | Time frame |
|---|---|
| disease-free survival;Throat preservation rate;Objective response rate;Local control rate;quality of life;security; | — |
Countries
China
Contacts
Public ContactLixiao Chen
Shanghai General Hospital
Outcome results
None listed