painless gastroscopy
Conditions
Interventions
one:Intravenous injection of different doses of rimimazolam
Sponsors
Zhuji People ' s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Gastroscopy ; 2. 18-65 years old ; 3. American anesthesiologist association ( ASA ) was graded as I – II ; 4. Body mass index ( BMI ) 18-28 kg / m2.
Exclusion criteria
Exclusion criteria: 1 Patients with severe respiratory diseases ( obstructive sleep apnea syndrome, acute respiratory infection, acute exacerbation of chronic obstructive pulmonary disease, uncontrolled asthma, etc. ) ; 2 Evaluation of patients with difficult airway ( modified Mallampati score IV, mouth opening limitation, mandibular, thyromental distance less than 6cm or less than the three transverse fingers ) ; 3 history of sleep apnea ; 4 patients with acute heart failure, unstable angina, and myocardial infarction within 6 months before screening ; 5 The hemodynamics was not stable ( systolic pressure [ SBP ] 180 mmHg, diastolic pressure DBP > 110 mmHg, and peripheral blood oxygen saturation [ SpO2 ] < 90 % ) ; 6 liver dysfunction ( aspartate aminotransferase ( AST ) and / or alanine aminotransferase ( ALT ) were higher than the 2.5 - fold normal upper limit, total bilirubin ( TBIL ) was higher than the 1.5 - fold normal upper limit, or renal dysfunction ( arginine or arginine nitrogen was higher than the normal upper limit, serum creatine was higher than the normal upper limit ) ; 7 patients with mental disorders ( schizophrenia, mania, bipolar disorder, mental disorders, etc. ), long-term use of psychotropic drugs, and cognitive impairment ; 8 Have a long history of taking mental or sedative hypnotic drugs. 9 History of drug abuse and alcohol consumption ( alcohol abuse : average daily consumption of more than 2 units of alcohol [ 1 unit = 360 mL beer or 45 mL 40 % liquor or 150 mL liquor ] ) ; 10 pregnant or lactating women, or family planning within 3 months ( including men ) ; 11 allergies or taboos against benzodiazepines, opioids, propofol and their components ; 12 patients who participated in other drug trials within three months before the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED90 of remimazolam combined with sufentanil in adult gastroscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Induction dose of rimimazom;time before falling asleep;examination time;Drug addition name;administration timing of drug;Arousal time after gastroscopy;systolic blood pressure;diastolic pressure;Mean arterial pressure;respiratory rate;heart rate;oxygen saturation; | — |
Countries
China
Contacts
Public ContactYan Chen
Zhuji People's Hospital
Outcome results
None listed