Skip to content

Programmed intermittent epidural anesthetic bolus for Labor Analgesia: the effect on Doppler flow velocity of umbilical arteries and uterine arteries with gestational hypertension. A randomized double-blind study in nulliparous women

Programmed intermittent epidural anesthetic bolus for Labor Analgesia: the effect on Doppler flow velocity of umbilical arteries and uterine arteries with gestational hypertension. A randomized double-blind study in nulliparous women

Status
Active, not recruiting
Phases
Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200062380
Enrollment
Unknown
Registered
2022-08-03
Start date
2023-01-01
Completion date
Unknown
Last updated
2023-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

flow velocity

Interventions

experimental group:Labor analgesia
control group:N/A

Sponsors

Hangzhou Women's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.singleton pregnancy at gestational age >= 37 weeks; 2. Age >= 18 years; 3. Active delivery (cervical dilation > 3 cm and uterine contractions at least every 5 min); 4. Gestational hypertension or preeclampsia; 5. ASA physical status I - II; 7. Obstetricians evaluate possible vaginal delivery.

Exclusion criteria

Exclusion criteria: 1. Contraindications to epidural anesthesia; 2. Diabetes mellitus, cardiovascular, respiratory or liver and kidney diseases, history of taking sedative or hypnotic drugs, history of neuropsychiatric diseases; 3. Participating in other clinical intervention trials; 4. Refused to participate in the study.

Design outcomes

Primary

MeasureTime frame
Pulsatile index of uterine artery in placental side of parturient women 30 min after programmed intermittent epidural anesthetic bolus for Labor Analgesia;

Secondary

MeasureTime frame
Pulsatile index, Resistance index (RI) and systolic-diastolic ratio (S/D) in maternal non-placental uterine artery, fetal umbilical artery and fetal middle cerebral artery (MCA);Puerpera BP, HR, SpO2, sensory block level, total amount of medication, additional times of controlled amount, labor course, delivery mode, satisfaction score of puerpera analgesia effect, postpartum bleeding amount, puerpera adverse reactions;Fetal heart rate (FHR), Apgar score, umbilical arterial and venous blood gases, gestational age, and birth weight;Neonatal resuscitation, rescue and neonatal complications;

Countries

China

Contacts

Public ContactMen Xin
rourouzong@163.com+86 15067196256

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026