macular disease(DME?AMD?CNV)
Conditions
Interventions
Mongolian group:Three & PRN
Han group:Three & PRN
Sponsors
Inner Mongolia Chaoju Eye Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Aged over 18 years old; (2) The patients were informed about the study and signed the informed consent form, and they were willing and carried out in accordance with the requirements of the clinical trial protocol; (3) Diabetic patients meet the diagnostic criteria for type 2 diabetes promulgated by WHO; (4) Meet the non-proliferative diagnostic criteria for diabetic retinopathy recommended by the American Academy of Ophthalmology and the International Academy of Ophthalmology in 2003, and meet the diagnostic criteria for diabetic macular edema; (5) Patients diagnosed with (wAMD containing PCV, DME, CNV) after fundus color photography, OCT/OCTA, FFA/ICGA examination; (6) BCVA is 0.05-0.5 (including 0.05 and 0.5); (7) There is macular edema in the OCT/OCTA examination, and the thickness of the central macular area within 1 mm in diameter is >=300 µm; (8) Nationality is determined by ID card registration.
Exclusion criteria
Exclusion criteria: (1) Severe refractive interstitial opacity, affecting the fundus observer; (2) Patients with fundus diseases such as glaucoma, retinal vein occlusion, uveitis, optic nerve disease; (3) Patients with poor general condition, serious cardiovascular and cerebrovascular, liver and hematopoietic diseases, diabetic nephropathy and renal failure, serious life-threatening primary diseases and mental illness; (4) Pregnant or lactating women (contraception during the study); (5) Those who are participating in clinical trials of other drugs; (6) Those who are unable to cooperate in completing various inspections due to age, disease, etc.; (7) Patients with poor compliance; (8) Received anti-VEGF or hormone therapy within 3 months; (9) Patients who have received retinal photocoagulation within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| General patient information;BCVA;CMT;NEI VFQ-25;Biochemical Indicators;IOP; | — |
Secondary
| Measure | Time frame |
|---|---|
| deep blood flow density;superficial blood flow density;Area of FAZ;Perimeter of FAZ;Complication; | — |
Countries
China
Contacts
Public ContactZhang Guisen
Inner Mongolia Chaoju Eye Hospital
Outcome results
None listed