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Study of the Mechanism of Acupuncture Lianquan (RN 23) with Different Frequency on Neuroplasticity in Brain Language Areas of Post-stroke Aphasia Based on Multi-modal MRI

Study of the Mechanism of Acupuncture Lianquan (RN 23) with Different Frequency on Neuroplasticity in Brain Language Areas of Post-stroke Aphasia Based on Multi-modal MRI

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200062340
Enrollment
Unknown
Registered
2022-08-02
Start date
2022-08-03
Completion date
Unknown
Last updated
2023-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post-stroke aphasia

Interventions

acupuncture group A:'Xing-Nao Kai-Qiao' acupuncture therapy plus acupuncture at lianquan(frequency:60times/min)
acupuncture group B:'Xing-Nao Kai-Qiao' acupuncture therapy plus acupuncture at lianquan(frequency:120times/min)
Control group:Acupuncture at the point which beside one Cun next to the acupoint

Sponsors

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 75 Years

Inclusion criteria

Inclusion criteria: Clinical participants 1)meet the diagnostic criteria for motor aphasia after stroke 2) Aphasia appears for the first time after stroke 3) Onset time ranged from 15 days to 3 months 4) The severity of aphasia is 0-3 5) Consciousness of consciousness and stable vital signs 6) Aged 45 to 75 years old 7) Volunteer the subjects and agree to sign the informed consent form. fMRI groups 1. Experimental group 1)was selected from the study trial group (before the intervention) 2)dextromanuality 3)The onset involved the language function area 4)Be able to complete the functional nuclear magnetic scanning 5)Volunteer the subjects, and agree to sign the informed consent form 2. Control group 1)was selected from the study trial group (before the intervention) 2)dextromanuality 3)The onset involved the language function area 4) Be able to complete the functional nuclear magnetic scanning 5) Volunteer the subjects, and agree to sign the informed consent form 3. Healthy group 1)Agegender and education level were matched with the patients in the experimental group 2)dextromanuality 3)Be able to complete the functional nuclear magnetic scanning 4)No cognitive impairment no diseases like brain trauma drugand alcohol dependence that may affect brain function and structure; 5)No mental symptoms such as depression; 6)Volunteer the subjects, and agree to sign the informed consent form;

Exclusion criteria

Exclusion criteria: Clinical participants 1)Patients with aphasia caused by other causes 2)Patients with aphasia before this onset 3)combined with severe primary diseases such as liver kidney hematopoietic system and endocrine system There are abnormalities in audio-visual severe cognitive impairment and mental illness which cannot be combined with examination and treatment 4)Patients currently undergoing verbal rehabilitation therapy or rTMS therapy for aphasia 5)Pregnant and lactating women.? fMRI groups: 1)consciousness impairment severe vision hearing impairment and other health assessments can not be completed 2)with cardiac pacemaker nerve stimulator artificial metal heart valve etc. aortic clamp (except for non-paramagnetic properties such as titanium alloy) Those with intraocular metal foreign objects inner ear implants metal prosthesis, metal joints, and ferromagnetic foreign bodies in the body who cannot be scanned or affect the image quality.

Design outcomes

Primary

MeasureTime frame
Western Aphasia Battery;Chinese functional communication profile;China?Rehabilitation Research Center Aphasia?Examination;Aphasia Battery of?Chinese;

Secondary

MeasureTime frame
Boston Diagnostic Aphasia Examination;Montreal?Cognitive Assessment;Mini-Mental State Examination;National Institute of Health stroke scale;Modified Rankin Scale,MRS;SAQOL-39 Quality of Life Scale;Stroke-specific Quality of Life Scale;the Health Scale of Traditional Chinese Medicine;Self-Rating?Anxiety?Scale;stroke aphasic depression questionnaire-hospital version;

Countries

China

Contacts

Public ContactShizhe Deng

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

18722498627@163.com+86 18722498627

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026