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Median effect compartment concentration EC50 for loss of consciousness induced by propofol during thoracoscopic lobectomy/segmental resection: comparison of general anesthesia versus general anesthesia with paravertebral block

EC50 of propofol

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200062327
Enrollment
Unknown
Registered
2022-08-01
Start date
2022-07-18
Completion date
Unknown
Last updated
2023-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

experimental group:para-vertebral block(ropivacaine)
control group:para-vertebral block (saline)

Sponsors

Zhejiang Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) for patients undergoing thoracoscopic lobectomy/segmental resection; (2) Older than 18 years old and younger than 70 years old; (3) ASA grade I -III; (4) Can cooperate with VAS pain scoring.

Exclusion criteria

Exclusion criteria: (1) Serious cardiopulmonary diseases, including but not limited to severe aortic stenosis, severe mitral stenosis, hemodynamic disorders caused by serious arrhythmias, acute cerebral infarction or myocardial infarction within the last 6 months, cardiac surgery within the last 6 months, etc. Upper respiratory tract infection or lung infection; (2) There are contraindications for paraspinal nerve block, such as puncture site infection, pyoses, kyphosis, previous pulmonary operation history and coagulation dysfunction; (3) Serious organ function diseases such as kidney disease and liver disease, etc. (4) Transfer to open surgery; (5) Opioids taken orally for more than 3 weeks before surgery; (6) The patient refused to participate in the study.

Design outcomes

Primary

MeasureTime frame
EC50 of propofol;

Secondary

MeasureTime frame
NRS score;

Countries

China

Contacts

Public ContactWen Zhang

Zhejiang Cancer Hospital

wendymos@126.com+86 15990145873

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026