Primary central nervous system lymphoma
Conditions
Interventions
Case series:ORT combined with/without high-dose MTX
Sponsors
The First Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed primary central nervous system B cell lymphoma by pathology; 2. With measurable lesions, brain-enhanced MRI parenchyma lesions (>10*10 mm); only meningeal lesions, require cytological examination of cerebrospinal fluid (CSF) to confirm lymphoma cells; 3. Age >= 18 years old; 4. ECOG 0-3; 5. Obtain the informed consent signed by the patient or his family.
Exclusion criteria
Exclusion criteria: 1. Received systemic or local treatment including chemotherapy in the first three weeks; 2. Liver and kidney function: blood bilirubin > 2mg / dl (35 µ AST / ALT was more than 2 times of the upper limit of normal, serum creatinine was more than 177 µ The creatinine clearance rate was less than 60 ml/min; 3. Normal heart function: EF <= 50%; 4. The expected survival time was less than 3 months; 5. chronic or current active infectious diseases requiring systemic antibiotics, antifungal agents or antiviral therapy; 6. Other concurrent and uncontrollable factors are considered by the researchers to affect the medical status of patients participating in the study. Psychiatric patients or other patients who are known or suspected to be unable to fully comply with the study protocol; 7. People living with HIV.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;Objective response rate;Progression free survival;Safety; | — |
Countries
China
Contacts
Public ContactJie Jin/Wenjuan Yu
Outcome results
None listed