Minor Recurrent Aphthous Ulcer
Conditions
Interventions
The experimental group:Biopeptide-containing repair toothpaste
The control group:Placebo toothpaste wtihous biopeptide
Sponsors
West China Hospital of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged range from 18 to 65 years; 2. History of recurrent Aphthous ulcer >=6 months, total occurrence times >=3; 3. Diagnosed as mild recurrent Aphthous ulcer, the number of ulcers was 1-3, and the diameter of ulcers was 2-9 mm; 4. The onset time of the ulcer was less than 48 hours without medication intervention; 5. The ulcer site is convenient for clinical examination; 6. Sign informed consent and be able to complete clinical trials as required.
Exclusion criteria
Exclusion criteria: 1. Recurrent herpetic Aphthous ulcer, Behcet's disease or other serious oral mucosal diseases (such as oral lichen planus, bullotic disease, oral candidiasis, etc.); 2. Suffering from serious systemic, infectious or autoimmune diseases; 3. Used glucocorticoids, immunosuppressive drugs, antibiotics, etc., within 1 month; used ulcer related local drugs within 1 week, etc.; 4. Allergic constitution or allergic history of the test product ingredients; 5. Laboratory inspection indicators are abnormal, exceeding 1.5 times of the upper/lower limit of normal value; 6. Patients of childbearing age during pregnancy, lactation or planning to become pregnant; 7. Smokers/alcoholics; 8. Participated in other clinical trials within 3 months; 9. Other circumstances not considered suitable for inclusion by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Target ulcer healing time;Ulcer pain index (Numerical rating scale (NRS) pain score);Healing rate of target ulcer; | — |
Secondary
| Measure | Time frame |
|---|---|
| Target ulcer area;Satisfaction of subjects using the experimental product; | — |
Countries
China
Contacts
Public ContactZhou Hongmei
West China Hospital of Stomatology, Sichuan University
Outcome results
None listed