Hyperuricemia with hypercholesterolemia
Conditions
Interventions
Experimental group:Taurine, allopurinol
Control group:Placebo, allopurinol
Sponsors
The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria for hyperuricemia with TC levels between 5.2 and 7.2 mmol/L; 2. Aged 18-60 years, male; 3. No recent (> 8 weeks) use of drugs that affect blood uric acid metabolism, including benzofuran derivatives (phenylbromarone, phenyliododarone), prosulfa, colchicine, salicylate (aspirin), selective and non-selective non-steroidal anti-inflammatory drugs, thiazines, furosemide diuretics, cyclosporin, pyrazinamide, losartan, etc., and patients who have taken other uric acid lowering measures; Or have stopped the drug for more than 2 weeks; 4. Cooperate with various research inspections and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Secondary hyperuricemia; 2. Gout or clinical manifestations of gout, including acute gouty arthritis, gouty stone and chronic arthritis, severe deformities, incapacitated persons, renal lesions; 3. Complicated with serious diseases of the heart, lung, brain, liver, kidney, hematopoietic system, including hepatitis B or C virus, kidney stones, polycystic kidney disease, hematologic malignancies or other unconfirmed malignant diseases and HIV; 4. Patients with a history of organ transplantation or extracorporeal circulation surgery; 5. Patients who participated in clinical trials of other drugs within 3 months; 6. The mentally ill; 7. Allergic constitution and multiple drug allergy (known allergy to allopurinol).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood uric acid;Total cholesterol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood creatinine;Urinary acid;24-hour uric acid excretion index;Urine creatinine;Triglyceride;Low density lipoprotein-cholesterol;High density lipoprotein-cholesterol; | — |
Countries
China
Contacts
Public ContactFu Bin
Outcome results
None listed