Diabetes
Conditions
Interventions
Control group:Normal saline
Sponsors
Longyan First Hospital Affiliated to Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. People diagnosed with type 2 diabetes according to the 1999 diagnostic criteria of the World Health Organization; 2. No gender limit, aged 18-79 years; 3. Voluntarily participate in the study, sign the informed consent and comply with the study protocol; 4. According to the Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes 2020 Edition, the five-item physical examination was consistent with the clinical diagnosis of distal symmetrical polyneuropathy.
Exclusion criteria
Exclusion criteria: 1. Have been treated with vitamin D2 injection within one month recently; 2. Allergic to vitamin D medications; 3. Parathyroid disease; 4. Alcohol or drug abusers; 5. Patients with hyperthyroidism or hypothyroidism; 6. Severe disability or mental illness; 7. Pregnant and lactating patients; 8. Those who plan long-term outdoor activities and frequent life in tropical areas; 9. Patients with blood calcium level exceeding 11mg/dl(2.75mmol/l), history of urinary tract calculi and sarcoidosis; 10. Stress diseases such as shortness of breath, acute chest pain, fever, diarrhea and other acute inflammation, severe leukopenia, malignant tumor, liver insufficiency (bilirubin >1.5 times the upper limit of normal value, alanine aminotransferase > 2 times the upper limit of normal value) or renal function decline eGFR10 mg/d glucocorticoid drugs; Renal rickets; 11. The patients were judged by the investigator to be unfit to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 25 hydroxyvitamin D;Michigan neuropathy screening insrtument; | — |
Secondary
| Measure | Time frame |
|---|---|
| Toronto clinical scoring system,TCSS;Fasting plasma glucose;Postprandial blood glucose;Glycosylated hemoglobin;Fasting C-peptide;Fasting insulin;Total cholesterol;Triglycerides;High-density lipoprotein cholesterol;Low-density lipoprotein cholesterol;Systolic blood pressure;Diastolic blood pressure;Body mass index;Serum calcium;Uric acid; | — |
Countries
China
Contacts
Public ContactChen Tao
Longyan First Hospital Affiliated to Fujian Medical University
Outcome results
None listed