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Efficacy and safety of Vonoprazan combined with high dose amoxicillin in the treatment of Helicobacter pylori infection

Efficacy and safety of Vonoprazan combined with high dose amoxicillin in the treatment of Helicobacter pylori infection

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200062264
Enrollment
Unknown
Registered
2022-07-31
Start date
2022-07-31
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori infection

Interventions

observation group 1:The treatment lasted for 10 days, including vonoprazan 20mg twice a day, amoxicillin 1g three times a day
observation group 2:The treatment lasted for 10 days, including vonoprazan 20mg twice a day, amoxicillin 1g three times a day, furazolidone 100mg twice a day
observation group 3:The treatment lasted for 14 days, including vonoprazan 20mg twice a day, amoxicillin 1g three times a day
control group:Amoxicillin 1g twice a day, clarithromycin sustained-release tablet 0.5g twice a day, rabeprazole sodium enteric-soluble capsule 20mg twice a day, colloidal bismuth 0.3g twice a day. Pat

Sponsors

Xuzhou First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-70 years, no gender limit; 2. The C13 breath test confirmed Helicobacter pylori infection; 3. Sign the informed consent and agree to follow the test requirements.

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating patients; 2. Patients with other serious diseases, such as heart disease, serious liver and kidney diseases, malignant tumors, etc.; 3. Patients with mental disorders or severe neurosis; 4. Patients who are allergic to medication.

Design outcomes

Primary

MeasureTime frame
The condition of Helicobacter pylori (Hp) infection;

Countries

China

Contacts

Public ContactChen Guangxia

Xuzhou First People's Hospital

gxchen_2010@163.com+86 13685135997

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026