Sepsis caused by intestinal ischemia-reperfusion injury
Conditions
Interventions
Postoperative intestinal injury group:None
Postoperative liver injury group:None
Sponsors
Nanfang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients waiting for elective heart surgery who are willing and able to give informed consent to participate in the study; 2. In sinus rhythm and not taking any antiarrhythmic drugs (other than beta-adrenergic blockers) at the time of surgery.
Exclusion criteria
Exclusion criteria: 1. History of obstructive hepatobiliary disease or other serious liver disease. 2. Untreated hypothyroidism. 3. Creatinine >200 umol/L. 4. Personal and family history of inherited muscle disorders. 5. Severe mitral valve disease (moderate or severe mitral regurgitation - e.g. > Grade II, and/or mitral stenosis and mitral ring calcification). 6. Patients receiving any antiarrhythmic medication (except beta-adrenergic blockers). 7. Intraaortic balloon support or aneurysm resection is required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| D-lactic acid;Diamine oxidase (DAO);Endotoxin;Citrulline;Intestinal fatty acid binding protein;Creatinine;Urea nitrogen;Bilirubin;Alanine aminotransferase;Aspartate aminotransferase;24-hour urine volume;C-reactive protein;Procalcitonin;Leukocyte count; | — |
Countries
China
Contacts
Public ContactLiu Kexuan
Nanfang Hospital of Southern Medical University
Outcome results
None listed