None listed
Conditions
Interventions
Group L:Intravenous infusion of lidocaine during anesthesia
Group D:Intravenous infusion of dexmedetomidine during anesthesia
Group R:Intravenous infusion of remimazolam during anesthesia
Group LD:Intravenous infusion of lidocaine and dexmedetomidine during anesthesia
Group LR:Intravenous infusion of lidocaine and remimazolam during anesthesia
Group C:Intravenous infusion of normal saline during anesthesia
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I-III; 2. Aged 60~80 years; 3. Elective posterior lumbar surgery under general anesthesia; 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Adults protected by law (under judicial protection, guardianship or supervision), persons deprived of their liberty; 3. Degree II or III atrioventricular block; 4. Heart failure; 5. History of Argus syndrome, preexcitation syndrome, or dysrhythmia; 6. Severe liver and kidney injury; 7. Patients with severe lung diseases; 8. History of epilepsy; 9. History of porphyria; 10. Preoperative hypotension (systolic blood pressure less than 90mmHg); 11. Contraindications of NSAIDs; 12. Allergic to narcotic drugs; 13. Actual weight < 40kg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative recovery quality scale 40 items;Arterial blood gas analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Activities of daily living;Cognitive function;Confusion;Bedside pulmonary ultrasound;Postoperative catheter-related-bladder discomfort;Postoperative sedation intensity;Postoperative sedation-agitation;Postoperative shivering;Postoperative pain;Postoperative gastrointestinal recovery and activity; | — |
Countries
China
Contacts
Public ContactXie Yubo
Department of Anesthesiology, the First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed