Gynecologic Oncology
Conditions
Interventions
quadratus lumborum group:0.3% ropivacaine + 0.9% normal saline to make a 50mL solution
Quadratus lumborum + esketamine group:0.3% ropivacaine + 0.25mg/kg esketamine + 0.9% normal saline to make a 50mL solution
Quadratus lumborum + dexmedetomidine group:0.3% ropivacaine + 0.5ug/kg dexmedetomidine + 0.9% normal saline to make a 50mL solution
Sponsors
Guangzhou Medical University Affiliated Cancer Hospital
Eligibility
Sex/Gender
Female
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Female patients undergoing elective radical resection of cervical cancer and endometrial cancer for the first time in Guangzhou Medical University Affiliated Cancer Hospital 2.Age 30-65 years old; 3.American Society of Anesthesiologists (ASA) grades I-II; 4.BMI index: 18-30 kg/m2; 5.The patients were conscious and understood the survey content; 6.Those who voluntarily participated in the study and had signed the informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with contraindications to nerve block: severe abnormal coagulation function, infection at the puncture site, local anesthetic toxicity, etc.; 2.Long-term drinking history, taking sedative drugs or antidepressants and other psychotropic drugs; 3.Combining other serious diseases of organs or systemic diseases such as Severe heart disease, severe liver and kidney failure; 4.taking other experimental drugs or participating in other clinical trials within 3 months before the study; 5.Follow-up visits, etc.; 6.There are contraindications to the use of esketamine and dexmedetomidine injection; 7.Other conditions that the researchers believe should not be included in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid consumption within 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative NRS score;Postoperative analgesia pump first compression time; | — |
Countries
China
Contacts
Public ContactTangchunlin
Outcome results
None listed