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Esketamine exerts anti shivering effect by regulating adipose tissue thermogenesis

Esketamine exerts anti shivering effect by regulating adipose tissue thermogenesis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200062169
Enrollment
Unknown
Registered
2022-07-27
Start date
2022-07-26
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

shivering

Interventions

Intervention group:ntravenous injection of esketamine

Sponsors

Tianjin Fourth Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age 18~70 years old; 2. ASA class ii~iii; 3. Patients diagnosed with renal tumor or gastrointestinal tumor and planned to undergo open tumor resection under general anesthesia

Exclusion criteria

Exclusion criteria: 1. Patients with liver dysfunction; 2. Patients with renal dysfunction; 3. Uncontrolled patients with severe and unstable angina pectoris, hyperthyroidism or hypothyroidism; 4. Restless patients unable to complete thermometry 5. Patients with severe hypertension, cardiovascular disease and arrhythmia, such as heart block and bradycardia; 6. Combined with increased intracranial pressure, central nervous system injury or disease, history of mental disorders, etc; 8. Patients receiving blood transfusion during enrollment; 9. Long term sedative and analgesic drug taking history and allergic history; 10. Patients with drug addiction before operation; 11. Patients who are allergic to any of the drugs used in the study; 12. Septic shock patients with circulatory instability;

Design outcomes

Primary

MeasureTime frame
body temperature;shivering effect;

Secondary

MeasureTime frame
blood presure;heart rate;Blood gas analysis;Blood oxygen saturation;routine blood test;VAS??;

Countries

China

Contacts

Public ContactDefang Xu

Tianjin Fourth Central Hospital

10772378@qq.com13803032095

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026