Effect of stress loading on periodontal tissue remodeling and its mechanism

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200062167

Enrollment

Unknown

Registered

2022-07-26

Start date

2022-09-01

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

malocclusion

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Orthodontic treatment was carried out for dentition irregularity, and a bilateral subtraction tooth extraction scheme was adopted in the treatment plan. 2.Patients who read the informed consent form (approved by the hospital ethics committee) and voluntarily participated in the project and signed it.

Exclusion criteria

Exclusion criteria: 1.Infectious and hereditary diseases; 2.Patients who do not meet the indications for tooth extraction and periodontal surgery; 3.Patients who are receiving radiotherapy or have received radiotherapy in recent 3 months; 4.Heart disease (i.e. grade II and above heart function disease); 5.Abnormal liver and kidney functions (abnormal liver ALT and AST values, or more than double the values of creatinine and urea nitrogen); 6.Mental disorder and lack of behavioral autonomy; 7.Patients with an allergic constitution; 8.Pregnant or lactating women

Design outcomes

Primary

Measure	Time frame
Histological analysis;Electron microscopy observation;RNA analysis;	—

Secondary

Measure	Time frame
Cytological observation;	—

Countries

China

Contacts

Public ContactLiting Jiang

Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University

drjiangliting@163.com13361981122

Outcome results