Lung Cancer
Conditions
Interventions
Group A:Wedge resection
Group B:Segmentectomy
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Department of Thoracic Surgery,Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Chin
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Chest computed tomography (CT) meets all of the following conditions: (a) Single tumor or multiple tumors, but other tumors other than the main lesion are expected to require no surgical intervention within 1 year; (b) Imaging is considered NSCLC; (c) The tumor center is located in the outer third of the lung field. 2.The tumor characteristics of thin-section CT also meet the following conditions: (a) The largest tumor diameter is less than or equal to 2 cm; (b) 0.25=the ratio of the largest diameter of the solid component of the tumor to its own largest diameter <1. 3.Patients aged 20–75 years. 4.No history of thoracic lung surgery (previous diagnostic thoracoscopy or mediastinal tumor resection are allowed). 5.Preoperative FEV1.0=1.5L. 6.ECOG grading of 0 or 1. 7.Sign the written informed consent. 8.The function of each organ can tolerate surgery. 9.Preoperative body temperature=38?. 10.Receive surgery within 30 days of initial registration. 11.Histologically confirmed adenocarcinoma, squamous cell carcinoma or other types of non-small cell lung cancer (detailed category unknown). 12.No malignant pleural effusion or pleural dissemination. 13.Wedge resection, segmentectomy and lymph node dissection are technically possible.
Exclusion criteria
Exclusion criteria: 1.Lymph node metastases are considered with radiologically evident; 2.Excision of the superior lobe or basal segment of left lung; 3.Active bacterial or fungal infection in lung; 4.History of other malignant tumors (excluding clinically cured malignant tumors, such as papillary thyroid carcinoma, breast cancer, clear cell renal carcinoma, etc.) 5.Pregnant or lactating women; 6.With interstitial pneumonia, pulmonary fibrosis or severe emphysema; 7.With mental disease; 8.Taking systemic steroid drugs; 9.With uncontrolled diabetes; 10.With uncontrolled hypertension; 11.History of severe heart disease, heart failure, myocardial infarction, or angina pectoris in the past 6 months. 12.Benign lesions were confirmed intraoperative or postoperative (including precancerous lesions: adenomatous hyperplasia). 13.Intraoperative exploration revealed obvious pleural invasion, pleural dissemination, malignant pleural effusion, and other situations that were not suitable for wedge resection or segmentectomy. 14.The minimum distance between the tumor edge and the staple incision edge is less than 2 cm, or less than the maximum diameter of the tumor. 15.No frozen pathological examination of N1 lymph node was performed during the operation, or cancer metastasis was found. 16.After being selected, the patients with severe preoperative complications (inability to tolerate surgery or anesthesia) are not suitable or unable to implement the treatment plan. 17.After the selection, the doctor in charge confirms that it is necessary to switch from elective surgery to emergency surgery due to the changes of patient's condition. 18.The patient voluntarily requests to withdraw or discontinue the treatment due to the patient's personal reasons at any stage after entering the study. 19.Implement treatment that violates the research protocol. 20.Those who have not undergone surgery within 30 days (including 30 days) after randomization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival;Disease free survival; | — |
Countries
China
Contacts
Public ContactShugeng Gao
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Chin
Outcome results
None listed