Hyperthyroidism
Conditions
Sponsors
Beijing Children's Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Age from 3 to 18 years old; 2.Meet the diagnostic criteria of clinical hyperthyroidism: a. Signs and symptoms of clinical hypermetabolism; b. Goiter and/or nodule; c. Serum thyroid function test: triiodothyronine Baseline data collection of children with hyperthyroidism in hyperthyroidism (TT3), total thyroxine (TT4), free triiodothyronine (FT3) and free thyroxine (FT4) levels Group microwave ablation parameters, ablation volume complications, serum thyroid function level, oral ATD, adverse event screening period, treatment period, recurrence rate increased, thyroid-stimulating hormone (TSH) level decreased (according to the standards adopted by the Laboratory Department of Beijing Children's Hospital Affiliated to Capital Medical University, The reference interval to define normal thyroid function in serum is: TT31.078-3.388nmol/L; TT451.5-173.8nmol/L; FT32.75-9.90pmol/L; FT48.37-29.6pmol/L; TSH0.4- 6.0mIU/L); 3.After receiving regular ATD treatment for 18-24 months, the hyperthyroidism continued to be unable to reduce or stop the drug; 4.The child had poor medication compliance, and the serum thyroid function level could not maintain a stable state; 5.recurrence after ATD treatment was discontinued; 6.the child could not tolerate adverse drug reactions, or the adverse drug reactions persisted; 7.the goiter progressively worsened during regular drug treatment, and symptoms of compression appeared; 8.patients with Children and/or guardians refused to undergo radioactive 131I therapy or thyroid surgery; 9.patients with thyroid nodules were confirmed to be benign nodules by biopsy; 10.bilateral vocal cord movements were normal in electronic laryngoscopy.
Exclusion criteria
Exclusion criteria: 1.severe cardiovascular disease, liver and kidney insufficiency, etc.; 2.severe coagulation dysfunction; 3.a history of neck radiation exposure or a family history of thyroid cancer; 4.bilateral vocal cord dysfunction; 5.Active infiltrative exophthalmos.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative improvement in symptoms of hyperthyroidism;Postoperative antithyroid drug reduction or withdrawal time;Hyperthyroidism recurrence;Complication rate; | — |
Countries
China
Contacts
Public ContactShi Wenyuan
Beijing Children's Hospital Affiliated to Capital Medical University
Outcome results
None listed