Effects of personalized embryo transfer guided by endometrial receptivity test (ERT) on pregnancy outcomes in dyslipidemic women with at least one prior failed embryo implantation

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200062118

Enrollment

Unknown

Registered

2022-07-23

Start date

2022-08-01

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

Experimental group - Dyslipidemia:ERT and pET

Experimental group - Normal blood lipids:ERT and pET

Control group - Dyslipidemia:conventional embryo transfer

Control group - Normal blood lipids:conventional embryo transfer

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Experimental group 1: 1.Infertile women seeking assisted reproductive technology because of tubal or male factors; 2.Women who had at least one prior failed embryo implantation in the first fresh embryo transfer or frozen embryo transfer (good-quality embryos transferred); 3.Women with dyslipidemia: TG>=1.7mmol/L or TC>=5.2mmol/L or LDL-C>=3.4mmol/L or HDL-C6); 8.at least one good-quality embryo left: D3 cleavage-stage embryo: >=7 cells, fragments=3BB; 9.Agree to perform ERT and undergo pET in the next FET cycle. Control group 1: The same as Experimental group 1 except for agreement for ERT. Experimental group 2: 1.Infertile women seeking assisted reproductive technology because of tubal or male factors; 2.Women who had at least one prior failed embryo implantation in the first fresh embryo transfer or frozen embryo transfer (good-quality embryos transferred); 3.Women with normal serum lipid level; 4.age between 20 and 40; 5.18.56); 8.at least one good-quality embryo left: D3 cleavage-stage embryo: >=7 cells, fragments=3BB; 9.Agree to perform ERT and undergo pET in the next FET cycle. Control group 2: The same as Experimental group 2 except for agreement for ERT.

Exclusion criteria

Exclusion criteria: 1.Endometrial lesions (IUA, endometrial polyps, tuberculosis, hyperplasia and untreated chronic endometritis; 2.Severe hydrosalpinx and did not receive tubal ligation or salpingectomy; 3.Submucous myomas, intramural hysteromyomas, or adenomyomas protruding towards the uterine cavity; 4.Endometriosis and adenomyoma; 5.Uterine and other reproductive system malformations; 6.Scar uterus; 7.Chromosomal abnormalities; 8.Previous embryo implantation with known embryo factor; 9.Recurrent pregnancy loss; 10.Patients with PGT; 11.Women with PCOS and DOR; 12.Oral contraceptive pills and treatment for hyperglycemia and dyslipidemia; 13.Women with hypertension, DM, thyroid dysfunction, PTS, APS, SLE, malignant tumor; 14.Other unsuitable situation.

Design outcomes

Primary

Measure	Time frame
intrauterine pregnancy rate;implantation rate;	—

Secondary

Measure	Time frame
ongoing pregnancy rate;live birth rate;	—

Countries

China

Contacts

Public ContactLi Yanping

liyanp@csu.edu.cn+86 13607317798

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026