Patients undergoing off-pump coronary artery bypass grafting
Conditions
Interventions
control:Injection of normal saline
Low dose group:Injection of low-dose tranexamic acid
High dose group:Injection of high-dose tranexamic acid
Sponsors
Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-80 years old; 2) Patients hospitalized in Fuwai Hospital and receiving elective OPCAB; 3) Agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Patients or family members refuse to participate; 2) Combined with other heart diseases or vascular malformations; 3) Previous heart or chest surgery; 4) Other operations or emergency operations were performed at the same time; 5) Preoperative left ventricular ejection fraction <30%;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cTni; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative bleeding;Activated Clotting Time(ACT);Blood products infusion;Length of hospitalization after operation;Secondary thoracotomy rate; | — |
Countries
China
Contacts
Public ContactYao Yuntai
Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Outcome results
None listed