gastric
Conditions
Interventions
single: neoadjuvant chemotherapy
Sponsors
The First Affiliated Hospital of USTC WEST district
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 75; 2. Gastric adenocarcinoma confirmed by histological or cytological pathology; 3. No surgery or chemotherapy was performed before diagnosis; 4. Diagnosis of locally advanced gastric cancer by imaging (CT) or laparoscopic exploration, cT3N+M0 or cT4NxM0; 5. ECOG (Eastern Cooperative Oncology Group) score 0-1; 6. Normal liver function, kidney function and bone marrow function; 7. Have at least one measurable lesion.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Previous history of malignant tumor; 3. Malignant tumors of other tissues except gastric cancer were found in the same period; 4. Known allergies to drugs used in the regimen, such as apatinib, oxaliplatin, capecitabine; 5. Known tendency of gastrointestinal bleeding; 6. Abnormal coagulation function; 7. Uncontrolled hypertension; 8. Previous history of myocardial infarction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pathologic response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| objective response rate;disease control rate;margin free resection rate;downstaging;adverse event; | — |
Countries
China
Contacts
Public ContactChen Xi
Outcome results
None listed