Hypertension
Conditions
Interventions
Standard treatment:Systolic blood pressure < 150mmHg
Standard treatment:Systolic blood pressure < 130mmHg
Sponsors
Daping Hospital Affiliated to Army Medical University
Eligibility
Sex/Gender
All
Age
80 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Men or women aged =80 years at the time of randomization. There is no upper age limit. To ensure that the patients are aged =80 years their date of birth will need to be confirmed by an official national document. 2. Hypertensive patients with SBP from 140 to 199 mmHg without medication or patients undergoing antihypertensive treatment. 3. Signed the written informed consent.
Exclusion criteria
Exclusion criteria: 1.SBP = 200 mmHg, or DBP 2.5mg/dl[> 221 µ mol/L]); 8. Symptomatic heart failure or reduced left ventricular ejection fraction (<40%) within the past 6 months; 9. Diagnosed atrial fibrillation; 10. Previous antihypertensive treatment with hypotensive events at SBP = 130 mmHg or clear evidence of intolerance of SBP = 130 mmHg; 11. Patients with a history of allergy to the study drug; 12. Participating in other clinical trials; 13. Unable to live in the selected center for a long time during the study period, which is not conducive to follow-up; 14. Patients with disabilities, mobility impairments, mental retardation, and other factors that may prevent them from participating in the study; 15. Patients with a poor compliance or otherwise deemed unsuitable for clinical trials by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure;Nonfatal stroke;Non fatal myocardial infarction;Acute heart failure;Coronary revascularization;Cardiovascular death; | — |
Secondary
| Measure | Time frame |
|---|---|
| Unstable angina pectoris;transient ischemic attack(TIA);New lacunar cerebral infarction;Hospitalization due to end point event;New onset atrial fibrillation;New onset diabetes;Decline of renal function or development of end-stage renal disease;All cause mortality;Routine blood test;electrolyte;Blood glucose;Blood lipid;Renal function;Hepatic function; | — |
Countries
China
Contacts
Public ContactZeng Chunyu
Outcome results
None listed