Stroke
Conditions
Interventions
Sham Repetitive Transcranial Magnetic Stimulation Group:Application of a sham stimulation coil with the selection of repetitive transcranial magnetic stimulation mode (10 Hz, 80% rMT, 5 seconds of sti
Active Repetitive Transcranial Magnetic Stimulation Group:Application of an active stimulation coil with repetitive transcranial magnetic stimulation mode (10 Hz, 80% rMT, 5 seconds of stimulation, 25
Sponsors
The Third Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.First-ever ischemic or hemorrhagic stroke. 2.Stroke lesion located in the cerebral cortex and/or subcortical regions. 3.Disease duration of 1-6 months. 4.Presence of cognitive impairment (MoCA = 2), no visual or auditory impairments preventing study participation. 8.If on cognitive enhancers (e.g., donepezil, memantine) or antidepressants, stable dosing for >= 2 weeks prior to enrollment; newly initiated medications must have been used for >= 2 weeks, with no intended changes in drug type or dosage during the study. 9.Provided written informed consent by subject or legally authorized representative.
Exclusion criteria
Exclusion criteria: 1.History of brain tumor, traumatic brain injury, hydrocephalus, epilepsy, or psychiatric disorders. 2.Neuroimaging revealed incomplete hematoma resolution following intracerebral hemorrhage, with residual abnormal signals observed in certain brain structures. 3.Neuroimaging findings demonstrating complete destruction of the left DLPFC. 4.Pre-existing cognitive impairment prior to stroke. 5.Status post craniotomy / cranial bone defect. 6.Presence of metallic or electronic implants (e.g., cochlear implants, deep brain stimulators, non-titanium aneurysm clips, or internal fixation devices following ventriculoperitoneal shunting). 7.Other serious medical conditions that may interfere with the study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Digit span, DS;Stroop Color-Word Test;Fugl-Meyer Assessment of Motor Function, FMA;Hamilton Depression Scale, HAMD;Modified Barthel Index, MBI;ApoE E3/3 OR E3/4;Cystatin C(CST3) B Allele;BDNF Val66Met (Val/Met or Met/Met);CAPN10 SNP43 G/A (GG); | — |
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment, MoCA; | — |
Countries
China
Contacts
Public ContactXiquan Hu
The Third Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed