Acute appendicitis
Conditions
Interventions
Group Rectal Indomethacin: Indomethacin is administered rectally
Group Lornoxicam: Lornoxicam intramuscularly or into pots
Sponsors
Beijing Luhe Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. 18-75 years old diagnosed with acute appendicitis; 2. Received LA; 3. Preoperative VAS score >2 points.
Exclusion criteria
Exclusion criteria: 1. Those with CONTRAINS to LA; 2. Refused or could not cooperate with the completion of this study; 3. Used other analgesic regimens before surgery; 4. Patients with any history of allergy to NSAIDs such as indomethacin and lornoxicam; 5. Patients with acute and chronic renal insufficiency, bronchial asthma, coagulation disorders, peptic ulcer diseases, and liver failure; 6. Patients who took NSAIDs or corticosteroids (due to chronic inflammatory diseases) within 48 hours; 7. Opioids or substance abusers;8. Pregnancy; 9. Receiving antidepressants 24 hours before surgery; 10. Patients with rectal, and other diseases that are not suitable for rectal administration; 11. Patients with missing clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time for first remediation of analgesia;The amount of postoperative analgesic drugs used;Postoperative VAS is less than 2 minutes;Incidence of nausea and vomiting;Gastrointestinal recovery time (exhaust time);white blood cell count(WBC);Central granulocyte percentage(N%);c reactive protein(CRP);procalcitonin(PCT);Appendicitis Inflammatory Response(AIR);Length of hospital stay;Hospitalization costs;Unplanned readmission rates;Immune indicators; | — |
Countries
China
Contacts
Public ContactLiu Yong
Beijing Luhe Hospital, Capital Medical University
Outcome results
None listed