Myocardial ischemia-reperfusion injury associated with cardiopulmonary bypass
Conditions
Interventions
None listed
Sponsors
First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years; 2. 18.5 kg/m2 ? BMI <= 35 kg/m2; 3. Patients undergoing cardiac surgery under elective cardiopulmonary bypass; 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Emergency; 2. Preoperative serum troponin or myoglobin was higher than normal; 3. Aortic dissection; 4. Ventriculotomy; 5. Resection of ventricular aneurysm; 6. Second heart surgery; 7. Combined with malignant tumors; 8. Non-cardiac surgery performed at the same time; 9. Liver and kidney insufficiency before operation; 10. Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Polyclonal Antibody to Solute Carrier Family 7, Member 11 (SLC7A11);Glutathione peroxidase (GPX4);Ferroportin (FPN);Malondialdehyde (MDA);L-Glutathione;Hypersensitive cardiac troponin T (hs-cTnT);Interleukin- 6;Myocardial histopathology;Ferroptosis suppressor protein 1;Prostaglandin endoperoxide synthase 2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Creatine kinase isoenzyme;Hemodynamics monitor;Myocardial strain; | — |
Countries
China
Contacts
Public ContactDeguang Feng
First Affiliated Hospital of Zhengzhou University
Outcome results
None listed