lung disease
Conditions
Interventions
Group 1 :1% lidocaine(1.5 mg/kg) is administrated intravenously at the induction of general anesthesia, followed by continuous infusion of 1% lidocaine at 1.5 mg/kg/h until the end of surgery
Control 2:At the anesthesia induction and during surgery, the same volume of 0.9% normal saline is given
Sponsors
Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who plan to undergo elective thoracoscopic surgery in the Department of Thoracic Surgery of Sichuan Provincial People's Hospital; 2. 18 years old <= age <= 80 years old; 3. ASA classification: I-III level; 4. Voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those with severe mental illness, such as schizophrenia, depression, dementia, etc.; 2. Combined with severe hepatic insufficiency (AST or ALT or bilirubin greater than 2.5 times the upper limit of normal), severe renal insufficiency (creatinine clearance rate less than 60 ml/min); 3. Those who are allergic to amide local anesthetics or have a history of epileptic seizures with II/III° atrioventricular block, severe sinus bradycardia or sick sinus syndrome; 4. Patients with Asperger's syndrome, pre-excitation syndrome, and severe heart block (including sinoatrial, atrioventricular, and intraventricular block); 5. History of taking chronic analgesics, opioid dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative pulmonary complications within 7days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Recovery Quality (QoR-40);Incidence of moderate to severe pain of 24h postoperatively at rest and during motion;Incidence of moderate to severe pain of 48h postoperatively at rest and during motion;The number of patients who need remedial analgesics;Adverse events of analgesics;The length of hospital stays; | — |
Countries
China
Contacts
Public ContactZeng Si
Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital
Outcome results
None listed