Correlation between nociceptin/orphanin FQ (N/OFQ) and perioperative myocardial injury in elderly patients with coronary heart disease

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200061976

Enrollment

Unknown

Registered

2022-07-14

Start date

2022-07-01

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular diseases

Interventions

Control 1:

Group 2:

Group 3:

Group 4:

Eligibility

Sex/Gender

All

Age

65 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients who signed the informed consent; 2. Patients aged 65-80 years old; 3. Patients with ASA grade II-III; 4. Patients with BMI of 19-27 kg/m2; 5. Coronary heart disease and non coronary heart disease patients who are scheduled for elective general anesthesia surgery.

Exclusion criteria

Exclusion criteria: 1. Patients with recent myocardial infarction (within 6 months); 2. Unstable angina pectoris; 3. Patients with a history of congenital heart disease; 4. Patients with history of cardiac surgery; 5. Patients with frequent ventricular or atrial premature beats, atrial fibrillation, heart conduction diseases and other serious arrhythmias; 6. Severe liver and kidney diseases; 7. Patients taking antiarrhythmic drugs in recent one week; 8. Patients with temporary or permanent pacemaker implantation.

Design outcomes

Primary

Measure	Time frame
Perioperative adverse cardiovascular events ;High-sensitivity cardiac troponin;N-telencephalic natriuretic peptide precursor;	—

Countries

China

Contacts

Public ContactChang Xiong

Affiliated Jinhua Hospital, Zhejiang University School of Medicine (Jinhua Central Hospital)

xiongchang811@163.com+86 17888299176

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026